Health
Breakthrough as cheap blood pressure drug fights deadly breast cancer
Breakthrough as cheap blood pressure drug fights deadly breast cancer
A cheap blood pressure drug taken by millions could help protect women against one of the deadliest forms of breast cancer, new research suggests.
Scientists at Monash University in Melbourne say beta blockers – which work by dampening the effects of stress hormones – may also halt the progression of triple-negative breast cancer in some patients.
The link between beta blockers and breast cancer first emerged in 2023, though it was not clear why. Now, researchers believe they have identified the mechanism – and with it a potential low-cost treatment for an extremely aggressive disease.
Their work looked at the interaction between two signalling molecules, cAMP and calcium, which accelerate cancer spread when a receptor called the beta-2 adrenoceptor is activated.
Stress hormones such as cortisol can trigger this receptor, fuelling tumour growth. But the team has now discovered that beta blockers can switch off a gene – HOXC12 – that drives this process, slowing the progression of the disease.
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The researchers said the breakthrough could help doctors identify, at the point of diagnosis, which patients are most likely to benefit from beta blocker therapy.
Beta blockers like atenolol work mainly by blocking the effect of stress hormones like adrenaline to slow down the heart. They are currently used to treat a number of conditions, including heart failure, high blood pressure and sometimes anxiety.
Professor Michelle Halls, senior author of the study and an expert in drug discovery biology at the Monash Institute of Pharmaceutical Sciences, said the findings were exciting, as they confirmed the potential link between beta blockers and tumour progression.
“Our colleagues previously found that beta blockers are associated with a significant reduction in mortality in people with triple-negative breast cancer. Now we have a much better grasp on why this could be the case,” she said.
Mr Terrance Lam, a pharmaceutical PhD candidate at the institute and co-author of the study, added: ‘Our collective research strongly suggests that HOXC12 is a potential new indicator for when triple negative breast cancer patients could respond to beta blocker targeted interventions.
“Triple negative breast cancer is an aggressive cancer which can be especially challenging to treat, and identifying new treatment pathways is important.”
The researchers are now calling for further studies to ‘urgently’ determine whether the gene can be used at diagnosis to identify patients who will benefit from beta blocker therapy – and stop their cancer spreading.
Beta blockers, commonly prescribed to lower blood pressure, work mainly by slowing the heart and blocking the action of stress hormones such as adrenaline.
According to the study, published in the scientific journal Science Signalling, there is a strong correlation between activation of the beta-2 adrenoceptor and accelerated cancer spread.
They also found that patients with high levels of HOXC12 expression were associated with poorer overall cancer survival outcomes.
Around 85 per cent of women diagnosed with breast cancer survive for more than five years following their diagnosis. However, triple negative breast cancer – which accounts for around 15 per cent of all breast cancers in the UK and US – is far more challenging to treat.
Typically, it grows and spreads faster than other breast cancer types and has fewer treatment options. One reason for this is because it doesn’t interact with hormones such as oestrogen in the same way as other breast cancers – for which there are targeted therapies.
On average around 77 per cent of women with triple negative breast cancer will survive their cancer for five years or more after they are diagnosed, but depending on the stage, this can fall as low as 12 per cent.
This is compared to around 90 per cent of women with other forms of breast cancer who will survive for at least five years.
Breakthrough as cheap blood pressure drug fights deadly breast cancer
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Health
Adamawa Health Officials Report 20 Deaths from Suspected Diphtheria Cases
Adamawa Health Officials Report 20 Deaths from Suspected Diphtheria Cases
Parents and caregivers are advised to seek early medical help and update childhood vaccinations as response teams expand outreach.
Health authorities in Adamawa State are responding to a diphtheria outbreak that has caused 20 deaths across 13 local government areas. Speaking on Wednesday, State Epidemiologist Jones Steven Kadabiyu confirmed that health workers have recorded 126 suspected cases throughout the state, with six patients currently receiving medical care in local hospitals.
Diphtheria is a serious bacterial illness that spreads through airborne droplets from coughing or close personal contact. It mainly affects the throat and airway, causing sore throats, mild fevers, swollen neck glands, and difficulty swallowing or breathing.
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Health officials emphasized that the biggest risk to patients has been waiting too long to visit a health center, as some families try informal remedies at home first before seeking professional medical attention.
The state government is working alongside health partners to track new cases, provide specialized antibiotics and treatments, and protect medical workers and family members.
Officials stressed that while diphtheria can affect people of any age, young children are the most vulnerable to serious complications. Parents and guardians are strongly encouraged to ensure their children are up to date on their routine vaccines and to visit the nearest clinic immediately if anyone develops throat swelling or breathing issues.
Adamawa Health Officials Report 20 Deaths from Suspected Diphtheria Cases
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Community
Monarch Dies Shortly After Being Rescued From Kwara Kidnappers
The Onigbesi of Igbesi Land in Kwara State, Oba Moses Oyinloye Iwedunmoye I, has died days after he was rescued from kidnappers.
The monarch passed away in the early hours of Saturday at a hospital, according to his son, Prince Olasunkanmi, who said his father had been receiving treatment following a brief illness.
“Yes, the news is true. He died after a brief illness following his release. We took him to the hospital, hoping he would survive, but he died there very early this morning,” Olasunkanmi said.
Oba Iwedunmoye was abducted on August 22 when armed men invaded Igbesi community in Isin Local Government Area.
He regained his freedom five days later after security forces launched an operation around the Elerin/Ijomu-Oro area, where three kidnapped victims were found.
The rescue followed a report received at the Oro Police Station from a vigilante member, who alerted authorities after one of his colleagues was shot while operating in the bush.
A combined team of police officers, soldiers and vigilantes was subsequently deployed to the area.
Police said the suspected kidnappers engaged the team in a gun battle after spotting the advancing operatives. One alleged kidnapper was killed during the exchange, while others escaped into the surrounding area.
The security team continued the search and eventually located the three victims, who were evacuated for medical treatment.
News of the monarch’s death was announced by Bisi Fakayode, National President of Omo Ibile Igbomina, who mourned the traditional ruler and prayed for the repose of his soul.
The circumstances surrounding the monarch’s illness and death have not been publicly disclosed beyond his family’s account that he fell ill after his release.
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Health
Ebola Crisis Deepens in DR Congo as Cases Cross 7,000
Ebola Crisis Deepens in DR Congo as Cases Cross 7,000
The Ebola outbreak in the Democratic Republic of Congo has reached more than 7,000 recorded cases, with nearly 3,400 people losing their lives in what authorities describe as the country’s worst epidemic of the disease.
Official figures show that 7,022 cases have been identified since the outbreak was detected in May. Of those affected, 3,398 have died, while 1,671 people have recovered.
The outbreak has also continued to expand geographically, with South-Ubangi becoming the seventh province where the virus has been detected. The province shares borders with both the Central African Republic and the Republic of Congo.
Health authorities are facing particular difficulties in Ituri, where most of the cases have been recorded. The province has schools where Ebola infections have been detected, raising concerns about further transmission as students return to classrooms.
Schools in affected areas have introduced additional precautions, including compulsory handwashing, limiting classroom numbers and discouraging physical contact among pupils.
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The response is being complicated by the wider conditions in eastern and northern parts of the country. Some affected communities are located in remote areas with limited healthcare facilities, while long-running armed conflicts have made access and government intervention more difficult.
Residents have expressed growing concern, particularly over the possibility of children carrying the virus between their homes and schools.
The current outbreak was first officially identified in northeastern Ituri in mid-May, although health authorities believe the virus may have been circulating for weeks before it was detected.
The strain responsible is Bundibugyo ebolavirus. There is currently no approved vaccine or treatment specifically available for the strain, although researchers are testing potential vaccines and therapies.
Ebola spreads primarily through contact with infected bodily fluids and can cause severe illness, including bleeding, organ failure and death.
The latest crisis is part of the DRC’s long history with Ebola, with the country experiencing 17 outbreaks since the virus was first identified there.
With infections continuing to appear in new areas, authorities face the challenge of containing transmission while providing treatment and protection in communities already struggling with insecurity and limited health infrastructure.
Ebola Crisis Deepens in DR Congo as Cases Cross 7,000
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