News
Another COVID-19 vaccine, Moderna, records 94.5% success
The quest for effective vaccines to combat the ravaging coronavirus has recorded another breakthrough with a United States-based biotech firm, Moderna Inc, saying on Monday that its experimental vaccine was 94.5 per cent effective in preventing the disease, according to an analysis of its clinical trial.
The report from multiple sources including BBC, Reuters and The Guardian comes a week after Pfizer and BioNTech said their vaccine was more than 90 per cent effective.
The results for both vaccines were from interim analyses of large clinical studies.
An interim analysis of the Moderna released on Monday, and based on 95 patients with confirmed COVID-19 infections found the candidate vaccine has an efficacy of 94.5 per cent.
In the result from the Moderna study, there were 30,000 volunteers; half got two doses of the vaccine 28 days apart; half got two shots of a placebo on the same schedule.
There were 95 instances of COVID-19 illness among the study participants — only five of those cases were in the vaccinated group. Ninety were in the group receiving the placebo.
Of these, there were said to be 11 cases of severe disease. The results indicate the vaccine was inducing the kind of immune response that protects people if they were exposed to the coronavirus.
Chief Executive Officer of Moderna, Stéphane Bancel, was quoted as saying in a statement, “This positive interim analysis from our Phase 3 study has given us the first clinical validation that our vaccine can prevent COVID-19 disease, including severe disease.”
Moderna said it had improved the shelf life and stability of its own vaccine, meaning that it can be stored at standard refrigeration temperatures of 2C to 8C for 30 days.
The company said it planned to apply to the US regulator, the Food and Drug Administration, for emergency-use authorisation in the coming weeks.
The results are the latest encouraging news to emerge from the breakneck effort to develop a vaccine against coronavirus and follow a similar interim analysis earlier this month from a collaboration between Pfizer and the German firm BioNTech, which suggest its vaccine is 90 per cent effective at preventing illness.
The Moderna vaccine is however not expected to be available outside the US until next year.
The biotech company said it would have 20m doses ready to ship in the US before the end of 2020 and hoped to manufacture 500 million to one billion doses globally next year.
So far, the UK does not stand to benefit from the vaccine. Moderna has agreed to provide the US with 100 million doses, with an option to buy 400m more. Japan, Canada, Switzerland, Qatar and Israel have also signed agreements, and the European commission has a “potential purchase agreement” for 80m-160m doses. The UK chose not to participate in the EU vaccine purchase scheme, with the health secretary, Matt Hancock, arguing in July that the government could source vaccine faster on its own. However, a Whitehall source said the UK government was in “advanced discussions” to procure doses of the Moderna vaccine.
The Moderna vaccine, which is based on similar mRNA technology as BioNTech’s, is expected to be assessed by the FDA on a final analysis of 151 COVID cases among trial participants who will be followed on average for more than two months.
If the results remain as impressive as the trial goes on, the Moderna vaccine could potentially provide a major advantage over the Pfizer vaccine.
While Pfizer’s vaccine requires ultracold freezing between -70C and -80C from production facility to patient, Moderna said it had improved the shelf life and stability of its own vaccine, meaning that it can be stored at standard refrigeration temperatures of 2C to 8C for 30 days.
It could be stored for six months at -20C for shipping and long-term storage, the company said.
Cost and side effects
At £38 to £45 for a course of two shots, Moderna’s vaccine is more expensive than the other frontrunners. AstraZeneca and Oxford University are aiming to sell their vaccine at about £3 a dose, while vaccines in trial with Johnson and Johnson and collaboration between Sanofi and GSK are both expected to cost about £8 a dose.
Pfizer is charging the US about £30 for a two-shot course. The UK has ordered 40 million Pfizer shots but none of the Moderna vaccine.
Moderna’s two-shot vaccine injects genetic material called mRNA into the body, which cells then use to churn out the spike protein the virus uses to invade cells.
The spike protein covers the surface of the virus and is one of the main targets of the body’s immune response to wipe out the infection.
A question mark that remains over the Pfizer vaccine is whether it prevents serious illness.
The Moderna results, released by an independent data safety monitoring board, are encouraging on this point. Of 11 participants who developed severe COVID while on the trial, all were in the placebo group. The results also suggest the vaccine is effective in older people and those from diverse ethnic backgrounds.
Moderna’s interim analysis includes a safety review of data available so far.
The company said it had found no significant safety concerns, with most reactions being mild to moderate and short-lived.
Among the side effects reported is the injection site pain in 2.7 per cent of trial volunteers after the first jab.
After the second, the most significant side effects include fatigue in 9.7 per cent, muscle pain in nine per cent and joint pain in five per cent. Others had headaches; others pains, or redness at the injection site.
Peter Openshaw, professor of experimental medicine at Imperial College, London, said the Moderna results were “tremendously exciting” and boosted optimism that a choice of good COVID vaccines would be available in the next few months.
News
Under-pressure AIG Okolo says state police comment personal opinion, not IGP’s
Under-pressure AIG Okolo says state police comment personal opinion, not IGP’s
Inspector-General of Police in charge of Information, Communications and Technology (ICT) at the Force Headquarters, Benjamin Okolo, may have been under pressure for saying Nigeria is not ripe for state police.
Since he represented the Inspector General of Police, Kayode Egbetokun, at a forum on Monday with former Nigeria’s presidents and leaders of thoughts, the statement was simply attributed to the IGP.
It was at a national dialogue on state police organised by the House of Representatives in Abuja.
Okolo however on Tuesday retracted the comment, saying he was not directed by IGP Egbetokun to disagree with the position of former Head of State, Gen. Abdulsalam Abubakar, and the former President, Goodluck Jonathan, on the issue of state police at the forum.
Okolo had also proposed that the Nigeria Security and Civil Defence Corps (NSCDC) and the Federal Road Safety Corps (FRSC) be merged to become a department under the police.
Newstrends had quoted Okolo as saying at the Monday forum, “It is the submission of the leadership of the Nigeria police force that Nigeria is yet to mature and ready for the establishment of state-controlled police.
“In view of this, the police leadership rather is recommending the following instead of creating state police.
“First, the Nigeria Security and Civil Defence Corps, Federal Road Safety to form a department under the Nigeria police.”
But in a U-turn, Okolo, at a press briefing at the Force Headquarters, Abuja on Tuesday, said he only made the comment in his personal capacity to stimulate the discourse, and not the official position of the IGP and the police force.
He said, “My expressions on state police at the session held at Abuja Continental Hotel on 22nd April, 2024 are my personal opinion to stimulate the discourse.
“They are not the views of the Inspector-General of Police or the Nigeria Police Force.”
News
Shun politicking, FG tells new 17 Chargé D’affaires, Consuls General
Shun politicking, FG tells new 17 Chargé D’affaires, Consuls General
The Federal Government has advised newly appointed five new Chargé D’affaires and 12 Consuls General to the nation’s mission in other countries to shun politicking and focus strictly on their job.
Minister of Foreign Affairs, Ambassador Yusuf Tuggar, gave the charge while unveiling the new appointees on Tuesday.
He also charged them to be good ambassadors of Nigeria.
A statement by Alkasim Abdulkadir, the minister’s Special Assistant on Media and Communications Strategy, gave these details.
While asserting that they were pivotal to the economic drive of President Bola Ahmed Tinubu, Tuggar further stressed that as seasoned career diplomats, they should recommit themselves to their calling of diplomacy for the collective interest and development of Nigeria.
Reacting on behalf of the new appointees, the just appointed Consul General for the Consulate in New York, Ambassador Abubakar Jidda, reiterated the commitment of his colleagues to uphold the ethos of the profession and pledged to bring the much-needed investments to the country.
He thanked President Bola Tinubu and the leadership of the Ministry of Foreign Affairs for the confidence reposed in them.
The new appointees are to resume immediately, the statement added.
FULL LIST:
Chargé D’affaires
Amb. Saidu Mohammed DODO, Damascus, Syria
Amb. Patrick Imoudu, IMOLOGHOME Pyongyang, Democratic Peoples’ Republic of Korea
Amb. Francisca Kemi OMAYULI
Singapore, Singapore
Amb. Babagana AHMADU
Bangui, Central African Republic
Amb. Mohammed MOHAMMED
Tripoli, Libya.
Consul General Conuslate
Amb. Auwalu Jega NAMADINA
Atlanta, USA
Amb. Nnamdi Okechukwu NZE
Bata, Equatorial Guinea
Amb. Francis Ntui ENYA
Douala, Cameroon
Amb. Gbadebo AFOLABI
Shanghai, China
Amb. Oludare Ezekiel FOLOWOSELE
Hong Kong, China
Amb. Abubakar JIDDA
New York, USA
Amb. Yakubu Audu DADU
Frankfurt, Germany
Amb. Taofik Obasanjo Coker
Buea, Cameroon
Amb. George Collins ONWUEKWE
Guangzhou, China
Amb. Umar Ibrahim BASHIR
Johannesburg, South Africa
Amb. Zayyan IBRAHIM
Dubai, UAE
Amb. Muazam Ibrahim Jibrin NAYAYA
Jeddah, Saudi Arabia
News
Produce copy of invitation to me, Bello challenges EFCC
Produce copy of invitation to me, Bello challenges EFCC
The former governor of Kogi State, Yahaya Bello, refuted allegations that he disregarded an invitation from the Economic and Financial Crimes Commission (EFCC).
According to the EFCC, Bello was summoned for interrogation on January 27 this year but failed to appear, leading to a declaration of him as a fugitive after an unsuccessful attempt to apprehend him at his Abuja residence.
In response to this claim, Bello’s media office issued a statement on Tuesday, challenging the accusations and urging the anti-graft agency to produce a copy of the invitation letter.
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The statement read, “Our attention has been drawn to a publication/press statement with the above title, issued by the Economic and Financial Crimes Commission (EFCC) on Monday, 22nd April, 2024, and signed by Wilson Uwujaren, its Acting Director of Public Affairs.
“In the said statement, which the Commission carefully circulated widely as usual, Mr. Uwujaren, who we have to believe is not a lawyer, continues the EFCC’s ongoing unconscionable lies against the former Governor of Kogi State, His Excellency, Yahaya Bello, CON, by labelling him as a fugitive from justice in order to disingenuously justify their established and willful pattern of defying lawful court orders.
“Contrary to Mr. Uwujaren’s claims, official records and court documents relating to their hounding of Alhaji Yahaya Bello establish a clear timeline of events. These documents are endorsed with dates and times of filing and payments, which are endorsed on court processes – all of which testify to the true sequence of events.”
The statement, signed by Ohiare Michael from Bello’s media office, dismissed the EFCC’s assertions and accused the agency of resorting to intimidation and harassment. It emphasized that while Bello respects the rule of law, he is not afraid of the EFCC.
Produce copy of invitation to me, Bello challenges EFCC
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