Another COVID-19 vaccine, Moderna, records 94.5% success – Newstrends
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Another COVID-19 vaccine, Moderna, records 94.5% success

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The quest for effective vaccines to combat the ravaging coronavirus has recorded another breakthrough with a United States-based biotech firm, Moderna Inc, saying on Monday that its experimental vaccine was 94.5 per cent effective in preventing the disease, according to an analysis of its clinical trial.

The report from multiple sources including BBC, Reuters and The Guardian comes a week after Pfizer and BioNTech said their vaccine was more than 90 per cent effective.

The results for both vaccines were from interim analyses of large clinical studies.

An interim analysis of the Moderna released on Monday, and based on 95 patients with confirmed COVID-19 infections found the candidate vaccine has an efficacy of 94.5 per cent.

 

 

In the result from the Moderna study, there were 30,000 volunteers; half got two doses of the vaccine 28 days apart; half got two shots of a placebo on the same schedule.

There were 95 instances of COVID-19 illness among the study participants — only five of those cases were in the vaccinated group. Ninety were in the group receiving the placebo.

Of these, there were said to be 11 cases of severe disease. The results indicate the vaccine was inducing the kind of immune response that protects people if they were exposed to the coronavirus.

Chief Executive Officer of Moderna, Stéphane Bancel, was quoted as saying in a statement, “This positive interim analysis from our Phase 3 study has given us the first clinical validation that our vaccine can prevent COVID-19 disease, including severe disease.”

Moderna said it had improved the shelf life and stability of its own vaccine, meaning that it can be stored at standard refrigeration temperatures of 2C to 8C for 30 days.

 

 

 

The company said it planned to apply to the US regulator, the Food and Drug Administration, for emergency-use authorisation in the coming weeks.

The results are the latest encouraging news to emerge from the breakneck effort to develop a vaccine against coronavirus and follow a similar interim analysis earlier this month from a collaboration between Pfizer and the German firm BioNTech, which suggest its vaccine is 90 per cent effective at preventing illness.

The Moderna vaccine is however not expected to be available outside the US until next year.

The biotech company said it would have 20m doses ready to ship in the US before the end of 2020 and hoped to manufacture 500 million to one billion doses globally next year.

So far, the UK does not stand to benefit from the vaccine. Moderna has agreed to provide the US with 100 million doses, with an option to buy 400m more. Japan, Canada, Switzerland, Qatar and Israel have also signed agreements, and the European commission has a “potential purchase agreement” for 80m-160m doses. The UK chose not to participate in the EU vaccine purchase scheme, with the health secretary, Matt Hancock, arguing in July that the government could source vaccine faster on its own. However, a Whitehall source said the UK government was in “advanced discussions” to procure doses of the Moderna vaccine.

The Moderna vaccine, which is based on similar mRNA technology as BioNTech’s, is expected to be assessed by the FDA on a final analysis of 151 COVID cases among trial participants who will be followed on average for more than two months.

If the results remain as impressive as the trial goes on, the Moderna vaccine could potentially provide a major advantage over the Pfizer vaccine.

While Pfizer’s vaccine requires ultracold freezing between -70C and -80C from production facility to patient, Moderna said it had improved the shelf life and stability of its own vaccine, meaning that it can be stored at standard refrigeration temperatures of 2C to 8C for 30 days.

It could be stored for six months at -20C for shipping and long-term storage, the company said.

 

 

Cost and side effects

At £38 to £45 for a course of two shots, Moderna’s vaccine is more expensive than the other frontrunners. AstraZeneca and Oxford University are aiming to sell their vaccine at about £3 a dose, while vaccines in trial with Johnson and Johnson and collaboration between Sanofi and GSK are both expected to cost about £8 a dose.

Pfizer is charging the US about £30 for a two-shot course. The UK has ordered 40 million Pfizer shots but none of the Moderna vaccine.

Moderna’s two-shot vaccine injects genetic material called mRNA into the body, which cells then use to churn out the spike protein the virus uses to invade cells.

The spike protein covers the surface of the virus and is one of the main targets of the body’s immune response to wipe out the infection.

A question mark that remains over the Pfizer vaccine is whether it prevents serious illness.

The Moderna results, released by an independent data safety monitoring board, are encouraging on this point. Of 11 participants who developed severe COVID while on the trial, all were in the placebo group. The results also suggest the vaccine is effective in older people and those from diverse ethnic backgrounds.

Moderna’s interim analysis includes a safety review of data available so far.

The company said it had found no significant safety concerns, with most reactions being mild to moderate and short-lived.

Among the side effects reported is the injection site pain in 2.7 per cent of trial volunteers after the first jab.

After the second, the most significant side effects include fatigue in 9.7 per cent, muscle pain in nine per cent and joint pain in five per cent. Others had headaches; others pains, or redness at the injection site.

Peter Openshaw, professor of experimental medicine at Imperial College, London, said the Moderna results were “tremendously exciting” and boosted optimism that a choice of good COVID vaccines would be available in the next few months.

 

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SERAP sues Wike, 36 govs over N5.9tn, $4.6bn loans

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SERAP sues Wike, 36 govs over N5.9tn, $4.6bn loans

Socio-Economic Rights and Accountability Project (SERAP) has filed a lawsuit against Nigeria’s governors and the Minister of the Federal Capital Territory, Abuja, Mr Nyesom Wike “over their failure to account for N5.9 trillion and $4.6 billion loans obtained by their states and the FCT, and to publish copies of the loan agreements, including details and locations of projects executed with the loans.”

The suit followed the disclosure last month by Governor Uba Sani of Kaduna State that the immediate past administration of Nasir El-Rufai left $587m, N85bn debt and 115 contractual liabilities, making it impossible for the state to pay salaries.

In the suit number FHC/ABJ/CS/592/2024 filed last Friday at the Federal High Court, Abuja, SERAP is asking the court to “direct and compel the governors and Mr Wike to account for N5.9trn and $4.6bn loans obtained by their states and the FCT and to publish copies of the loan agreements, location of projects executed with the loans.”

SERAP is also asking the court to “direct and compel the governors and Mr Wike to invite the Economic and Financial Crimes Commission (EFCC) and the Independent Corrupt Practices and Other Related Offences Commission (ICPC) to investigate the spending of all the loans obtained to date by their states and the FCT.”

In the suit, SERAP is arguing that “It is in the public interest to grant the reliefs sought. Nigerians have the right to see and scrutinise the loan agreements and know the details of how the domestic and external loans obtained by the governors and FCT minister are spent.”

According to SERAP, “Opacity in the spending of the loans obtained by the governors and Mr Wike would continue to have negative impacts on the fundamental interests of the citizens.”

SERAP is also arguing that, “Many states and the FCT are reportedly spending public funds which may include the loans obtained by them to fund unnecessary travels, buy exotic and bulletproof cars and generally fund the lavish lifestyles of politicians.”

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SERAP is also arguing that, “Many states and the FCT are also allegedly mismanaging public funds which may include domestic and external loans obtained from bilateral and multilateral institutions and agencies.”

According to SERAP, “Many states and the FCT reportedly owe civil servants’ salaries and pensions. Several states are borrowing to pay salaries. Millions of Nigerians resident in the state and FCT continue to be denied access to basic public goods and services such as quality education and healthcare.”

According to SERAP, “Transparency in the spending of the loans obtained by the states and FCT is fundamental to increase accountability, prevent corruption, and build trust in democratic institutions with the ultimate aim of strengthening the rule of law.”

The suit filed on behalf of SERAP by its lawyers Kolawole Oluwadare, Kehinde Oyewumi and Ms Valentina Adegoke, read in part: “States and the FCT should be guided by transparency and accountability principles and proactively account for the loans obtained and publish copies of the loan agreements.”

“Widely publishing copies of the loan agreements and spending details of the loans obtained would ensure that persons with public responsibilities are answerable to the people for the performance of their duties in the management of public funds.”

“State governors and Mr Wike cannot hide under the excuse that the Freedom of Information Act is not applicable to their states and the FCT. The legal obligations to publish the information sought are also imposed by the provisions of the Nigerian Constitution and the African Charter on Human and Peoples’ Rights.”

“According to Nigeria’s Debt Management Office, the total public domestic debt portfolio for the country’s 36 states and the Federal Capital Territory is N5.9 trillion. The total public external debt portfolio is $4.6 billion.”

“The domestic and external loans obtained by the states and the FCT are vulnerable to corruption and mismanagement. The states and FCT have a responsibility to ensure transparency and accountability in how any loans obtained by the states and FCT are spent, to reduce vulnerability to corruption and mismanagement.”

“Directing and compelling the states and FCT to publish copies of the loan agreements would allow Nigerians to scrutinise them, and promote transparency and accountability on the spending of public funds including the loans obtained.”

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“Providing and widely publishing the details of the spending of the domestic and external loans obtained by the states and FCT would enable Nigerians to effectively and meaningfully engage in the management of the loans.”

“The constitutional principle of democracy also provides a foundation for Nigerians’ right to know the details of loan agreements and how the loans obtained are spent. Citizens’ right to know promotes openness, transparency, and accountability that is in turn crucial for the country’s democratic order.”

“The effective operation of representative democracy depends on the people being able to scrutinize, discuss and contribute to government decision making, including on the spending of loans obtained by the states and FCT.”

“To do this, they need information to enable them to participate more effectively in the management of public funds by their state governments and the FCT.”

“The public interest in obtaining information about expenditures relating to the loans obtained by the states and FCT outweighs any privacy or other interest.”

“The oversight afforded by public access to such details would serve as an important check on the activities of the states and FCT and help to prevent abuses of the public trust.”

“There is a significant risk of mismanagement or diversion of funds linked to loans obtained by state governments and the FCT. The accounts of Nigeria’s 36 states and the FCT are generally not open to public scrutiny.”

“The Nigerian Constitution, human rights and anticorruption treaties to which Nigeria is a state party also impose obligations on the states and FCT to prevent mismanagement or diversion of public funds including the loans obtained.”

“Many years of allegations of corruption and mismanagement of public funds including the loans obtained by the states and FCT have contributed to widespread poverty, underdevelopment and lack of access to public goods and services.”

No date has been fixed for the hearing of the suit filed by SERAP.

SERAP sues Wike, 36 govs over N5.9tn, $4.6bn loans

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Just in: List of ex-governors under probe over N2.187tn fraud fabricated, says EFCC

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Just in: List of ex-governors under probe over N2.187tn fraud fabricated, says EFCC

The Economic and Financial Crimes Commission (EFCC) has denied releasing a list of ex-governors being investigated for alleged corruption.
It described the list currently being circulated as a mere fabrication and urged members of the public to ignore it.
This was disclosed in a statement by Dele Oyewale, EFCC’s head of media and publicity.
It declared the report published by some media as “false and mischievous”.
The EFCC Press Statement
List of Ex- Govs Under Investigation for Alleged Corruption Not From EFCC

The Economic and Financial Crimes Commission, EFCC, feels obliged to dissociate itself from a phantom report circulating in sections of the media claiming it has released a full list of ex- governors being investigated for alleged corruption.
The report headlined: “EFCC Releases Full List of 58 Ex-Governors that Embezzled N2 .187 Trillion”, in one of the news outlets, is false and mischievous as the Commission neither issued the said list nor entertained discussions on investigation of ex-governors with any news medium.
This invariably means that the so-called list is a disingenuous fabrication designed to achieve motives known only to the authors.
The public is enjoined to ignore the report as it is false and misleading.
The media is advised to endeavour to crosscheck facts pertaining to matters under investigation with the Commission to avoid misleading the public with false and inaccurate reports.

Dele Oyewale
Head, Media & Publicity
May 5, 2024

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Nigeria to reduce electricity supply to Niger Republic, Benin, Togo

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Nigeria to reduce electricity supply to Niger Republic, Benin, Togo

Not more than six per cent of total electricity from the national grid will be supplied to cross-border customers in Benin Republic, Niger and Togo.

The Nigerian Electricity Regulatory Commission (NERC) gave this directive to the System Operator (SO), a department in the Transmission Company of Nigeria (TCN).

NERC said this was done in a bid to increase power availability to Nigerians.

This is coming as the Minister of Power, Adebayo Adelabu, has reportedly disclosed that the Federal Government and the Nigerian Sovereign Investment Authority (NSIA) would make capital injections of N750 billion and N250 billion annual debt financing to bridge the huge electricity metering gap in the country that currently stands at about seven million, according to a ThisDay report.

These details are contained in a document tagged: ‘Interim Order on Transmission System Dispatch Operations, Cross-border Supply and Related Matters’.

The power sector regulator stated that the directive would last for six months in the first instance before a review.

Nigeria supplies a portion of the electricity it generates to some of its neighbours such as the Benin Republic, Niger Republic and Togo.

NERC’s order, dated April 29, 2024, and which became effective from May 1, 2024, was signed by the commission’s Chairman, Sanusi Garba, and Vice Chairman, Musiliu Oseni.

The electricity sector regulator stressed that following the implementation of the April 2024 supplementary order, the commission had observed sub-optimal grid dispatch operation practices.

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It argued that this had compromised the Distribution Companies’ (Discos) ability to deliver on its Service Based Tariff (SBT) committed service levels to end-use customers with a significant impact on market revenues.

NERC said the system operator’s sole reliance on limiting Discos’ load off-take/allocation in managing recurring grid imbalances while prioritising international off-takers and Eligible Customers (ECs) is neither efficient nor equitable.

The practice so far adopted by the operator in managing generation availability, it said, had caused significant hardship to Discos’ customers, comprising industrial, commercial, and residential, especially during peak demands while prioritising delivery to other bilateral contracts, including export to international customers.

“The commission hereby orders as follows: The system operator shall develop and present to the commission for approval within seven days from the issuance of this order a pro-rata load-shedding scheme that ensures equitable adjustment to load allocation to all off-takers — Discos, international customers, and eligible customers — in the event of a drop in generation and other under-frequency related grid imbalances necessitating critical grid management.

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“The system operator shall implement a framework to log and publish hourly readings and enforce necessary sanctions for violation of grid instructions and contracted nominations by off-takers in line with the grid code and market,” it stated.

Among others, it further directed that the system operator shall publish and notify all market participants and the commission of the previous day’s hourly log readings of off-take by market participants and the market settlements report by 12:00 noon of the next day.

“The system operator shall ensure that the maximum load allocation to international off-takers in each trading hour shall not be more than six per cent of the total available grid generation.

“The aggregate capacity that can be nominated by a generating plant to service international off-takers shall not be more than 10 per cent of its available generation capacity unless in exceptional circumstances a derogation is granted by the commission.

“The system operator shall henceforth cease to recognise any capacity addition in bilateral transactions between a generator and an off-taker without the express approval of the commission,” it added.

It urged the system operator and TCN to immediately initiate and install integrated Internet of Things (IoT) meters at all off-take and delivery points of eligible customers, bilateral supplies, cross-border trades, and outgoing 33kV feeders of the Discos to provide real-time visibility of aggregate off-take by grid customers.

“The installation of and streaming of data from the IOT meters should be completed within three months from the date of this order,” it added.

Nigeria to reduce electricity supply to Niger Republic, Benin, Togo

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